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KMID : 0380620140460010094
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Korean Journal of Food Science and Technology
2014 Volume.46 No. 1 p.94 ~ p.99
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Anti-mycobacterial Effects of the Extract of Humulus japonicus
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Hong Min-Sun
Son Eun-Soon
Lee Sung-Joong
Lee Sun-Kyoung
Song Sun-Dae
Cho Sang-Nae
Clifton E. Barry III
Eum Seok-Yong
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Abstract
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The present study aimed to evaluate the in vitro antimycobacterial effects of hop plant, Humulus japonicus. Methanol extract of H. japonicus (MeOH extract) showed strong direct bactericidal effects against Mycobacterium tuberculosis in vitro. Furthermore, the MeOH extract significantly inhibited M. tuberculosis growth in human macrophages. When five fractions obtained from MeOH extract were examined using the same methods, the hexane and ethyl acetate fractions showed bactericidal effects against M. tuberculosis in vitro, whereas the butanol and water fractions inhibited M. tuberculosis growth in macrophages. Because H. japonicus extract exhibited antimycobacterial activity against both free M. tuberculosis in culture medium and intracellular M. tuberculosis in human macrophages, this plant might be a good candidate for development of a new anti-tuberculosis drug.
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